Background: Electroconvulsive therapy is one of the most effective treatments for major depressive disorder. Recently, there has been increasing attention to evaluate the effect of ECT on resting-state functional magnetic resonance imaging. This study aims to compare rs-fMRI of depressive disorder patients with healthy participants, investigate whether pre-ECT dynamic functional network connectivity network estimated from patients rs-fMRI is associated with an eventual ECT outcome, and explore the effect of ECT on brain network states.Method: Resting-state functional magnetic resonance imaging data were (...) collected from 119 patients with depression or depressive disorder, and 61 healthy participants, with an age mean of 52.25 years old. The pre-ECT and post-ECT Hamilton Depression Rating Scale were 25.59 ± 6.14 and 11.48 ± 9.07, respectively. Twenty-four independent components from default mode and cognitive control network were extracted, using group-independent component analysis from pre-ECT and post-ECT rs-fMRI. Then, the sliding window approach was used to estimate the pre-and post-ECT dFNC of each subject. Next, k-means clustering was separately applied to pre-ECT dFNC and post-ECT dFNC to assess three distinct states from each participant. We calculated the amount of time each subject spends in each state, which is called “occupancy rate” or OCR. Next, we compared OCR values between HC and DEP participants. We also calculated the partial correlation between pre-ECT OCRs and HDRS change while controlling for age, gender, and site. Finally, we evaluated the effectiveness of ECT by comparing pre- and post-ECT OCR of DEP and HC participants.Results: The main findings include depressive disorder patients had significantly lower OCR values than the HC group in state 2, where connectivity between cognitive control network and default mode network was relatively higher than other states, Pre-ECT OCR of state, with more negative connectivity between CCN and DMN components, is linked with the HDRS changes. This means that those DEP patients who spent less time in this state showed more HDRS change, and The post-ECT OCR analysis suggested that ECT increased the amount of time DEP patients spent in state 2.Conclusion: Our finding suggests that dynamic functional network connectivity features, estimated from CCN and DMN, show promise as a predictive biomarker of the ECT outcome of DEP patients. Also, this study identifies a possible underlying mechanism associated with the ECT effect on DEP patients. (shrink)

The most arresting aspect of the Scottish Enlightenment is its conception of commercial society as a distinct and distinctive social formation. Christopher Berry explains why Enlightenment thinkers considered commercial society to be wealthier and freer than earlier forms, and charts the contemporary debates and tensions between Enlightenment thinkers that this idea raised. The book analyses the full range of literature on the subject, from key works like Adam Smith's 'Wealth of Nations', David Hume's 'Essays and Treatises on Several Subjects' (...) and Adam Ferguson's 'Essay on the History of Civil Society' to lesser-known works such as Robert Wallace's 'Dissertation on Numbers of Mankind'. (shrink)

This chapter suggests that descriptive epidemiological studies like the Global Burden of Disease Study can usefully be divided into four tasks: describing individuals’ health states over time, assessing their health states under a range of counterfactual scenarios, summarizing the information collected, and then packaging it for presentation. The authors show that each of these tasks raises important and challenging ethical questions. They comment on some of the philosophical issues involved in measuring health states, attributing causes to health outcomes, choosing the (...) counterfactual against which to assess causes, aggregating and summarizing complex information across multiple domains, discounting, age-weighting, handling fetal deaths, measuring health inequalities, representing uncertainty, and assessing personal responsibility for health outcomes. (shrink)

The relatively recent increase in empirical research conducted in business ethics has been accompanied by a growing literature which addresses its present shortcomings and continuing challenges. Particular attention has been focused on the difficulties of obtaining valid and reliable primary data. However, little or no attention has been paid to the use of secondary data. The aim of this paper is to stimulate the interest of business ethics researchers in using secondary data, either as a substitute or complement for primary (...) data, bearing in mind both the benefits and shortcomings of doing so. It is suggested that secondary data not only offer advantages in terms of cost and effort, as conventionally described in research methods books, but also that in certain cases their use may overcome some of the difficulties that particularly afflict business ethics researchers in the gathering of primary data. In order to help business ethicists respond to this call for greater consideration of the potential offered by secondary data, the wide variety of forms that such data may take is indicated and a number of themes regarding their use discussed. (shrink)

The increasing demands placed on private welfare services and calls for business to fulfil its social responsibilities have heightened interest in corporate charitable donations in the United Kingdom. Adjustments to the corporation tax system have been made to encourage companies to give more. The article outlines the legal and fiscal background to company giving, examines its magnitude and reports on a survey of company practice.

Kant actively struggles with the problem of how to conceive of God's creative action in relation to human freedom. He comes to the view that human freedom can only be protected if God withdraws in certain ways from the created world. The two pillars of Kant's mature philosophy - transcendental idealism and freedom - are in part shaped and motivated by Kant's need to provide a solution to his theological problem. The medieval and early modern theological tradition conceives of divine (...) action as unlike the action of any created being. When the creature acts, God directly causes this action, but without reducing the creature's freedom. Kant explicitly discusses and rejects this account of divine and human concursus. This rejection has significant and surprising ramifications for Kant's wider philosophy, explaining otherwise incomprehensible claims in his critical philosophy. Christopher J. Insole presents a definitive study in the history of ideas, engaging with a wide range of Kant's texts from 1749 until the early 1800s. Many of these texts have received little or no attention in Kant studies to date. Insole places Kant's thought in relation to numerous historical and traditional positions and illuminates these positions by a close engagement with recent debates in analytical philosophy and systematic theology. Kant is unrelentingly honest when grappling with the difficulty of relating divine and human freedom. This study, of Kant's theological struggle and legacy, goes to the heart of the problem in the modern reception of what the Christian tradition has affirmed about human freedom. As such, the book throws light on one of the defining fault-lines in modern theology and philosophy. (shrink)

In this article, we review approaches to modeling a connection between spatial and mathematical thinking across development. We critically evaluate the strengths and weaknesses of factor analyses, meta-analyses, and experimental literatures. We examine those studies that set out to describe the nature and number of spatial and mathematical skills and specific connections between these abilities, especially those that included children as participants. We also find evidence of strong spatial-mathematical connections and transfer from spatial interventions to mathematical understanding. Finally, we map (...) out the kinds of studies that could enhance our understanding of the mechanisms by which spatial and mathematical processing are connected and the principles by which mathematical outcomes could be enhanced through spatial training in educational settings. (shrink)

The purpose of this article is to explore the relationship between revolution and violence in Marxism and in a series of texts drawing on Marxian theory. Part 1 outlines the basic normative frameworks which determine the outer limits of permissible violence in Marxism. Part 2 presents a critical analysis of a series of later discussions - by Sorel, Fanon and Žižek - which transformed the terms in which violence was discussed by developing one particular aspect of Marxist thought. By teasing (...) out the implications of revolutionary theory for the commission and permission of violence, it is possible to specify those points at which it tends towards excess. This in turn points towards limits that an adequate normative theory of revolutionary violence should establish. (shrink)

Whether or not youth work should professionalise and to what degree governments should regulate youth work services have been a widely debated topic within the Australian youth sector in recent tim...

Although business ethics has a long history as a core theme within the realm of strategic management it has not received considerable attention in top strategy journals until recently. In this paper, we assess the state of business ethics research published over a 5-year period (2006–2010) in Strategic Management Journal to ascertain whether there has been an increase in business ethics research published in the top strategy outlet. The results of our content analysis reveal that ethics research in SMJ is (...) indeed on the rise yet this research stream is still underrepresented with only 5.8 % of all articles published over the five-year period having an ethics theme. Moreover, the link between Corporate Social Performance and Financial Performance was identified as the top theme during the review period. (shrink)

Benbaji and Statman’s contractarian ethics of war offers a powerful new philosophical defence of orthodox conclusions against revisionist criticism. I present a two-pronged argument in reply. First, contractarianism yields what I call ‘decent war theory,’ a theory in which war between decent states is paradigmatic. I argue, by contrast, that states should treat wars against indecent states as paradigmatic, resulting in a Rawlsian alternative that issues in an ethics closer to revisionism. The second prong argues that the symmetrical international distribution (...) of power required by contractarianism throws into doubt the viability of war as an instrument for securing just ends. But I argue that there is a very important lesson to take from Benbaji and Statman’s analysis here. Even if contractarianism is arguably weakened by its political assumptions, revisionists frequently fail to pay any attention to the vagaries of power and their effects in shaping the outcomes of different accounts of ethics. I therefore argue that just war theory in general ought to develop an ethics with sufficient versatility to respond to shifts and variations in the distribution of military power. In particular, philosophers must consider morally defensible ways in which decent states can challenge rising indecent powers. (shrink)

According to contemporary ‘process ontology’, organisms are best conceptualised as spatio-temporally extended entities whose mereological composition is fundamentally contingent and whose essence consists in changeability. In contrast to the Aristotelian precepts of classical ‘substance ontology’, from the four-dimensional perspective of this framework, the identity of an organism is grounded not in certain collections of privileged properties, or features which it could not fail to possess, but in the succession of diachronic relations by which it persists, or ‘perdures’ as one entity (...) over time. In this paper, I offer a novel defence of substance ontology by arguing that the coherency and plausibility of the radical reconceptualisation of organisms proffered by process ontology ultimately depends upon its making use of the ‘substantial’ principles it purports to replace. (shrink)

The first comprehensive collection of the work of Richard Rorty, The Rorty Reader brings together the influential American philosopher’s essential essays from over four decades of writings. Offers a comprehensive introduction to Richard Rorty's life and body of work Brings key essays published across many volumes and journals into one collection, including selections from his final volume of philosophical papers, Philosophy as Cultural Politics ) Contains the previously unpublished essay, “Redemption from Egotism” Includes in-depth interviews, and several revealing autobiographical pieces (...) Represents the fullest portrait available today on Rorty’s relationship with American pragmatism and the trajectory of his thought. (shrink)

This article examines and contextualizes a health wish formula found at the opening of eight Roman official letters inscribed in Greek, one of Caesar and seven of Octavian. In each letter the sender mentions that he is well ‘with the army’ (μετὰ τοῦ στρατεύματος), hence the term ‘military’ health wish. The health wish was borrowed from Latin letters into Roman letters written in Greek by means of phraseological imitation. The formulation employs appropriate Koine Greek. It was optional during the Republic (...) for the wish to be used in letters either from or to a Roman holding imperium and commanding an army. Because Caesar and Octavian were in such positions, their use of the wish is conventional. The use of this health wish demonstrates that epistolographers working for Caesar and Octavian not only drafted letters that met the conventions of Hellenistic chanceries but also were proficient enough in the medium to incorporate Roman elements with effectiveness. Attestations of the military health wish declined during the Imperial period. The requirement that the sender or the recipient hold imperium would have restricted usage during the Republic but even more so under the Empire through administrative changes to the command of armies and the increasing centrality of the princeps. (shrink)

This paper argues that the reason why political leadership often involves dirty hands is because of its relationship with violence. To make the case, it maintains that violent means create and assert a form of dominating power that is in tension with the proper ends of political action. This power casts a wide shadow, frequently dominating large numbers of non-targets and empowering unscrupulous agents. On the other side of the balance, characteristically political justifications for violence are ‘supra-moral,’ meaning that they (...) are motivated by the value of a conception of morality taken as a whole (or, indeed, morality as such) rather than by any particular moral value. The weight that ought to be given to such ends is indeterminate in a way that makes uncancelled remainders arising from the evil of violence likely in many cases. (shrink)

I suggest that in Kant’s conception of autonomy, we have a faithful variant of a perennial philosophical conception of divinity, distinctively re-configured by Kant’s own preoccupations and system, but still recognisably oriented around some philosophical conceptions of the divine, which have their origins in deep classical wells, with dreams and memories of thought-thinking-itself, and joyously diffusing itself, generating plenitude and harmony. If this is correct, then we might find that the most interesting dialogue in the realm of ‘public theology’ is (...) not necessarily between Christianity and secularism, but between Christianity and a latent pagan religious philosophy, that draws upon a perennial strand of Platonism in Western philosophy. (shrink)

Extinction is usually associated with the death of the last remaining individual of a species, taxon, or population of organisms. Here I ask the question of whether extinction might also be applied to cases where individuals of the relevant category remain alive. Global impacts in the Anthropocene suggest extinction may be broader than typically thought. Technologies available in the emerging ‘synthetic age’ alter taxa in ways that may appropriately be characterized as extinction. The core of the more traditional account of (...) extinction remains valuable. Losing the last few individuals of a taxon matters. But emerging types of loss may demand a broader understanding of extinction. This broader understanding could capture more of what humans are doing to the biosphere. (shrink)

The philosopher Kant is a key thinker in shaping our contemporary concept of morality, freedom, and happiness. This book argues that Kant believes in God, but that he is not a Christian, and that this opens up an important and neglected dimension of Western Philosophy.

This essay seeks to illuminate the ethical concerns that animate Richard Rorty's philosophy. I argue that Rorty's ethics foregrounds as its central priority the issue of responsibility and frame Rorty's work as offering us a picture of ethical comportment in a postfoundational, pluralistic milieu, where citizens not only recognize the contingency of their own deepest beliefs but give up any sense of responsibilities owed to nonhuman authorities. To paraphrase Rorty, from any number of occasions, all we have to be responsible (...) to is each other. Yet Rorty goes even further than antiauthoritarianism in ethics. He not only shifts to thinking about ethics in terms of our relations to others; he specifically attunes this ethics to those who are suffering or excluded or merely previously unnoticed. What emerges is an alternative Rorty to the smirking gadfly blithely shrugging off criticism and incapable of inhabiting a position of moral seriousness. (shrink)

He asks what these ideas in contemporary epistemology and environmental philosophy mean for environmental policy, concluding that the grounding of knowledge strongly suggests epistemic reasons for the protection of a full range of physical environments in their natural condition."--BOOK JACKET.

This paper examines the debate between permissive and impermissive forms of Bayesianism. It briefly discusses some considerations that might be offered by both sides of the debate, and then replies to some new arguments in favor of impermissivism offered by Roger White. First, it argues that White’s (Oxford studies in epistemology, vol 3. Oxford University Press, Oxford, pp 161–186, 2010) defense of Indifference Principles is unsuccessful. Second, it contends that White’s (Philos Perspect 19:445–459, 2005) arguments against permissive views do not (...) succeed. (shrink)

The ability of international ethics and political theory to establish a genuinely critical standpoint from which to evaluate uses of armed force has been challenged by various lines of argument. On one, theorists question the narrow conception of violence on which analysis relies. Were they right, it would overturn two key assumptions: first, that violence is sufficiently distinctive to merit attention as a category separate from other modes of human harming; second, that it is troubling in a special way that (...) makes acts of violence peculiarly hard to justify. This paper defends a narrow understanding of violence and a special ethics governing its use by arguing that a distinctive form of ‘Violent Agency’ is the factor uniting the category while partly accounting for the fearful connotations of the term. Violent Agency is defined first by a double intention (1) to inflict harm using a technique chosen (2) to eliminate or evade the target’s means of escaping it or defending against it. Second, the harms it aims at are destructive (as opposed to appropriative). The analysis offered connects the concept of violence to themes in international theory such as vulnerability, security, and domination, as well as the ethics of war. (shrink)

For many Americans, the election of Barack Obama as the country's first black president signaled that we had become a post-racial nation - some even suggested that race was no longer worth discussing. Of course, the evidence tells a very different story. And while social scientists are fully engaged in examining the facts of race, normative political thought has failed to grapple with race as an interesting moral case or as a focus in the expansive theory of social justice. Political (...) thought's under participation in the debate over the status of blacks in American society raises serious concerns since the main academic task of political theory is to adjudicate discrepancies between the demands of ideal justice and social realities. Christopher J. Lebron contends that it is the duty of political thought to address the moral problems that attend racial inequality and to make those problems salient to a democratic polity. Thus, in The Color of Our Shame, he asks two major questions. First, given the success of the Civil Rights Act and the sharp decline in overt racist norms, how can we explain the persistence of systemic racial inequality? Second, once we have settled on an explanation, what might political philosophy have to offer in terms of a solution? In order to answer these questions Lebron suggests that we reconceive of racial inequality as a condition that marks the normative status of black citizens in the eyes of the nation. He argues that our collective response to racial inequality ought to be shame. While we reject race as a reason for marginalizing blacks on the basis of liberal democratic ideals, we fail to live up to those ideals - a situation that Lebron sees as a failure of national character. Drawing on a wide array of resources including liberal theory, virtue ethics, history, and popular culture, Lebron proposes a move toward a "perfectionist politics" that would compel a higher level of racially relevant moral excellence from individuals and institutions and enable America to meet the democratic ideals that it has set for itself. (shrink)

By utilizing the topological concept of pseudocompactness, we simplify and improve a proof of Caicedo, Dueñez, and Iovino concerning Terence Tao's metastability. We also pinpoint the exact relationship between the Omitting Types Theorem and the Baire Category Theorem by developing a machine that turns topological spaces into abstract logics.

kant famously rules out the possibility of any knowledge of God’s existence or non-existence.1 In denying the possibility of knowledge about God, Kant departs from his rationalist sources, and from his own earlier position. Leibniz, Wolff, Locke, Crusius, Meier, and Baumgarten all assert that we can have knowledge of the existence and properties of God.2 Although he finds that there is an absence of evidence sufficient for knowledge about God’s existence, or non-existence, this is not, for Kant, a disordered or (...) regrettable deficit. Indeed, Kant finds it “providential” that God has not permitted such knowledge. Kant even tells us that we should “thank heaven”... (shrink)

Debates over the existence of intrinsic value have long been central to professional environmental ethics. Holmes Rolston, III’s version of intrinsic value is, perhaps, the most well known. Recently, powerful critiques leveled by Bryan G. Norton and J. Baird Callicott have suggested that there is an epistemological problem with Rolston’s account. In this paper, I argue first that the debates over intrinsic value are as pertinent now as they have ever been. I then explain the objections that Norton and Callicott (...) have raised against Rolston’s position. In the main body of the paper, I attempt to show that Rolston’s position can accommodate these objections. In this defense of Rolston’s position, I have two goals: first, to show that the notion of non-subjective intrinsic value in nature is coherent, and second, to illuminate the places where further philosophical work on intrinsic value remains to be done. (shrink)

The prelims comprise: Justificatory Liberalism Justificatory vs. Mere Liberalism Why Public Justification? The Argument from Respect Evaluation of Larmore's Argument from Respect A General Problem for the Argument from Respect The Argument from Religious Warfare The Argument from Divisiveness What Is Public Justification? Conclusion Notes Bibliography.

The use of focus groups is a well‐established qualitative research method in the social sciences that would seem to offer scope for a significant contribution to the advancement of knowledge and understanding in the field of business ethics. This paper explores the potential contribution of focus groups, reviews their contribution to date and makes some recommendations regarding their future use. We find that, while the use of focus groups is not extensive, they have been utilised in a non‐negligible number of (...) studies. Focus groups are usually used as a supplementary method, often as part of the development of a research instrument. Whether used on their own or in conjunction with other methods, we find that in the majority of cases there is insufficient information for a reader to judge that the method has been carried out well and hence that the ‘findings’ may be trusted. Nor is it easy for future researchers to learn about the practical application of the method in business ethics contexts. We therefore recommend improved reporting in future published studies. Based on an analysis of a subsample of papers that provided a reasonable level of methodological detail, we provide further insights into, and recommendations for, the use of focus groups in business ethics research. (shrink)

We describe an infinitary logic for metric structures which is analogous to Lω1,ω. We show that this logic is capable of expressing several concepts from analysis that cannot be expressed in finitary continuous logic. Using topological methods, we prove an omitting types theorem for countable fragments of our infinitary logic. We use omitting types to prove a two-cardinal theorem, which yields a strengthening of a result of Ben Yaacov and Iovino concerning separable quotients of Banach spaces.

John Rawls’s articulation of what makes for justice in war includes one of his most interesting, yet least discussed, assessments of religion and state coercion. Rawls claims that “the duties of the statesman in political liberalism” are incompatible with adherence to “the Catholic doctrine of double effect” when that doctrine precludes the deliberate targeting of innocent and harmless human beings in a “supreme emergency.” I explicate Rawls’s argument in favor of that claim, articulate various theological objections, and assess some proposed (...) restrictions on the justificatory role of religious reasons in the light of that disagreement. (shrink)

The well-justified claim on the cover of this beautifully produced volume is that it is a “uniquely authoritative history of [Western] philosophy for the general reader.... Personalities and ideas are brought to life.... The contributors... bring to their chapters not only deep understanding, but also enthusiasm and zest for their subject.” The combination of pace, intelligence, and intelligibility that pervades most of the book is exemplary. It is a thoroughly engaging read, not least because of the contributors’ readiness to say (...) frankly when the characters in the story commit themselves to what is unclear, absurd, or downright false. If there is an underlying theme, it is that we must rid ourselves of the notion that there is any clear linear progress in philosophy: “classics in philosophy are not antiquated by succeeding research in the way that the works of even the greatest scientists become dated in time”. If there is progress at all, it comes in the shape of the recognition of earlier philosophers’ mistakes and the salvaging of “partial insights.” But “ ‘we must assume that even the best efforts of our own time will come to seem blind eventually’ ”. The latter page, the last of the text and of the afterword, is by happily symbolic error headed “Ancient Philosophy”; to adapt the title of one of the early illustrations of the book, readers by this point may appropriately wonder where they are coming from, and where they are going..). (shrink)